Here at BCM Fareva UK, we use spectroscopy to aid in the support of various pharmaceutical services. Spectroscopy analysis is required in a number of monographs. It is also often a requirement in ICH, MHRA and FDA regulations. We have a full spectroscopy suite to aid us in spectroscopy techniques. But, what is spectroscopy and why is it important? In this article, we’ll look at the various types of spectroscopy and the uses we at BCM have for it.
Spectroscopy is the study of wavelengths and the interaction between matter and electromagnetic radiation. It involves studying the absorption, emission and reflection of radiation by matter.
Spectroscopy studies underpin the fundamental principles of science, for example, quantum mechanics and the special and general theories of relativity.
Spectroscopy has played a vital role in the world of pharmaceuticals. Here at BCM we use spectroscopy equipment to identify compounds and verify purities. We use the interaction between electromagnetic radiation matter to achieve this.
Within pharmaceuticals, we use a range of processes and variations of spectroscopy. Each variation has its own pros and cons.
We use this form to atomise samples and create small polyatomic ions. To do this, we inductively couple plasma to ionise samples, which we then detect.
This technique is used to detect metals present with samples. We base this technique on ground state metals absorbing light at specific wavelengths. Metal ions within solutions are then converted to an atomic state by flame.
We use this system for the assay of dyes in finished products. Using ultraviolet light to study the absorption of products. This is typically used within sunscreen testing.
We use this as an analytical technique to identify organic materials. This technique measures the absorption of infrared radiation by the various wavelengths of sample materials.
We use near infrared spectrometry to identify raw materials. It works by using near infrared regions of the electromagnetic spectrum.
X-ray powder diffraction is used to analyse powder and solid raw materials. For identification and ploy morph testing
Energy dispersive x-ray fluorescence is for elemental identification and quantification. Doubly curved crystal optics direct an intense micron-sized monochromatic X-ray beam to the sample surface for enhanced elemental analysis.
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